羟氯喹和柳氮磺胺吡啶单药及联合用药治疗类风湿关节炎：一项随机双盲试验
Hydroxychloroquine and sulphasalazine alone and in combination in rheumatoid arthritis: a randomised double blind trial.
作者信息
Faarvang K L, Egsmose C, Kryger P, Pødenphant J, Ingeman-Nielsen M, Hansen T M
机构信息
Department of Rheumatology, Kong Christian d X's Gigthospital, Graasten, Denmark.
出版信息
Ann Rheum Dis. 1993 Oct;52(10):711-5. doi: 10.1136/ard.52.10.711.
OBJECTIVES
To compare the effects of hydroxychloroquine and sulphasalazine alone and in combination in rheumatoid arthritis.
METHODS
A six month randomised, multicentre, double blind trial with three parallel groups was performed. Ninety one outpatients with active rheumatoid arthritis were included. Monthly assessments of erythrocyte sedimentation rate, morning stiffness, number of swollen joints, a pain score, and global assessments were carried out. Radiographs of hands and wrists were taken before and after the trial.
RESULTS
Sixty two patients completed the study. The 29 withdrawals caused no evident bias, and there was no difference in side effects among the three groups. All variables improved significantly with time. Patients treated with a combination of hydroxychloroquine and sulphasalazine responded better and faster than those treated with hydroxychloroquine alone, but there was no statistically significant difference between the combination treatment and single drug treatment with sulphasalazine or between treatment with hydroxychloroquine and sulphasalazine given alone.
CONCLUSION
The present results do not support a recommendation to use a combination of hydroxychloroquine and sulphasalazine in the treatment of rheumatoid arthritis.
目的
比较羟氯喹和柳氮磺胺吡啶单独及联合使用对类风湿关节炎的疗效。
方法
进行了一项为期六个月的随机、多中心、双盲试验，设有三个平行组。纳入91例活动性类风湿关节炎门诊患者。每月对红细胞沉降率、晨僵、关节肿胀数、疼痛评分和整体评估进行测定。试验前后拍摄双手和手腕的X线片。
结果
62例患者完成研究。29例退出者未造成明显偏倚，三组间副作用无差异。所有变量均随时间显著改善。联合使用羟氯喹和柳氮磺胺吡啶治疗的患者比单独使用羟氯喹治疗的患者反应更好、更快，但联合治疗与单独使用柳氮磺胺吡啶单药治疗之间或羟氯喹与柳氮磺胺吡啶单独治疗之间无统计学显著差异。
结论
目前的结果不支持在类风湿关节炎治疗中联合使用羟氯喹和柳氮磺胺吡啶的建议。
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