Ravnborg L, Thomsen K
Department of Dermatology, Rigshospitalet, Copenhagen, Denmark.
Acta Derm Venereol. 1993 Oct;73(5):378-9. doi: 10.2340/0001555573378379.
A case of acanthosis nigricans associated with a metastatic adenocarcinoma is presented. To our knowledge this is the first one reported in the literature. The primary tumour is unknown, but it is presumably a cholangiocarcinoma. The skin changes preceded the detection of malignancy by 2 years, during which the skin lesions progressed though the patient was still in good health. If malignant acanthosis nigricans is suspected and the underlying malignancy cannot be found at the initial screening, repeated screenings are necessary because of the time factor.
本文报告一例与转移性腺癌相关的黑棘皮病。据我们所知，这是文献中首次报道的病例。原发肿瘤不明，但推测可能是胆管癌。皮肤改变在恶性肿瘤被发现前2年就已出现，在此期间，尽管患者仍健康状况良好，但皮肤病变仍在进展。如果怀疑是恶性黑棘皮病，且在初次筛查时未发现潜在的恶性肿瘤，由于时间因素，重复筛查是必要的。
