Kligman L H, Crosby M J
University of Pennsylvania, School of Medicine, Department of Dermatology, Philadelphia 19104-6142, USA.
Cancer Lett. 1996 Oct 22;107(2):217-22. doi: 10.1016/0304-3835(96)04377-7.
The role of retinoids in hairless mouse photocarcinogenesis has been studied extensively but remains controversial. By contrast, the role of corticosteroids has hardly been investigated. Many findings indicate an antagonism between the action of these two drugs. To examine these issues, we irradiated hairless mice thrice weekly for 10 weeks with 1.5 minimal erythema doses of solar simulating radiation (UVB + UVA). In the post-UV period, groups of mice were treated topically for 30 weeks with tretinoin, corticosteroid or emollient vehicle alone or with a sequential combination of corticosteroid and tretinoin. A control group remained topically untreated. All three agents, when used alone, significantly inhibited tumorigenesis. The sequential combination produced the greatest inhibition.
维甲酸在无毛小鼠光致癌作用中的角色已得到广泛研究，但仍存在争议。相比之下，皮质类固醇的作用几乎未被研究。许多研究结果表明这两种药物的作用之间存在拮抗作用。为了研究这些问题，我们每周三次用1.5个最小红斑量的模拟太阳辐射（UVB + UVA）照射无毛小鼠，持续10周。在紫外线照射后的时期，将小鼠分组，分别单独局部使用维甲酸、皮质类固醇或润肤剂载体，或皮质类固醇与维甲酸的序贯组合进行治疗，持续30周。一个对照组保持局部不治疗。所有三种药物单独使用时均显著抑制肿瘤发生。序贯组合产生的抑制作用最大。
