Hull H F, Ward N A, Hull B P, Milstien J B, de Quadros C
Expanded Programme on Immunization, World Health Organization, Geneva, Switzerland.
Lancet. 1994 May 28;343(8909):1331-7. doi: 10.1016/s0140-6736(94)92472-4.
With more than 2 years having elapsed since the last case of paralytic poliomyelitis occurred in the Western Hemisphere, significant progress has been made towards the global eradication of wild polioviruses. Poliomyelitis is disappearing from Europe, North Africa, Southern Africa, the Middle East, China, and the Pacific. Reported poliomyelitis cases declined to 15,587 cases in 1992. Current eradication strategies recommended by the World Health Organization include national mass campaigns administering oral poliovaccine to all children under 5 years of age, enhanced surveillance to detect cases of acute flaccid paralysis, creating a network of laboratories for viral diagnosis, and targeted immunisation to areas and populations where poliovirus transmission is likely to persist. The major obstacles to eradication include inadequate political support for eradication and insufficient funding, especially for the purchase of vaccine. With additional support for the international eradication effort, epidemics of poliomyelitis will cease in developing countries, and industrialised countries will be able to save the large sums spent each year on poliovaccine and rehabilitation.
自西半球出现最后一例麻痹性脊髓灰质炎病例至今已过去两年多,全球根除野生脊髓灰质炎病毒工作取得了重大进展。脊髓灰质炎正在从欧洲、北非、南非、中东、中国和太平洋地区消失。1992年报告的脊髓灰质炎病例降至15,587例。世界卫生组织目前建议的根除策略包括针对所有5岁以下儿童开展口服脊髓灰质炎疫苗全国大规模接种运动、加强监测以发现急性弛缓性麻痹病例、建立病毒诊断实验室网络以及对脊髓灰质炎病毒传播可能持续存在的地区和人群进行目标免疫。根除工作的主要障碍包括对根除工作的政治支持不足和资金短缺,特别是购买疫苗的资金。随着对国际根除工作的更多支持,脊髓灰质炎疫情将在发展中国家停止,工业化国家也将能够节省每年在脊髓灰质炎疫苗和康复方面花费的大量资金。