Cooksey R C, Thorne G M, Farrar W E
Antimicrob Agents Chemother. 1976 Jul;10(1):123-7. doi: 10.1128/AAC.10.1.123.
Nineteen of 39 multiresistant strains of Serratia marcescens isolated from clinical sources transferred antibiotic resistance to Escherichia coli or Klebsiella pneumoniae recipients. Marcesins and/or phage prevented effective resistance transfer to E. coli and attempts to select marcescin-resistant mutants of the E. coli recipient strain were unsuccessful. Transfer of resistance was demonstrated for all drugs tested except nalidixic acid. Approximately 90% of donors resistant to tobramycin, ampicillin, or carbenicillin transferred resistance to these drugs. High levels of transferred resistance (minimal inhibitory concentration, >2,500 mug/ml) were demonstrated particularly for ampicillin, carbenicillin, and kanamycin. Transmissibility of Serratia R factors was greatest between isogeneic strains of E. coli K-12. Comparative rates of spontaneous loss of R factor-mediated resistance indicated that Serratia R factors are less stable in E. coli and K. pneumoniae transcipients than in the indigenous hosts.
从临床来源分离出的39株多重耐药粘质沙雷氏菌中有19株将抗生素耐药性转移给了大肠杆菌或肺炎克雷伯菌受体。粘质菌素和/或噬菌体可阻止耐药性有效转移至大肠杆菌，并且尝试筛选大肠杆菌受体菌株的粘质菌素耐药突变体未成功。除萘啶酸外，对所有测试药物均证实了耐药性的转移。对妥布霉素、氨苄西林或羧苄西林耐药的供体中约90%将对这些药物的耐药性进行了转移。尤其对于氨苄西林、羧苄西林和卡那霉素，显示出高水平的转移耐药性（最低抑菌浓度，>2500μg/ml）。粘质沙雷氏菌R因子在大肠杆菌K-12的同基因菌株之间的可传递性最强。R因子介导的耐药性自发丧失的比较率表明，粘质沙雷氏菌R因子在大肠杆菌和肺炎克雷伯菌受体中比在原生宿主中更不稳定。
