Ihn H, Fujimoto M, Sato S, Kikuchi K, Igarashi A, Soma Y, Takehara K
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
J Am Acad Dermatol. 1994 Oct;31(4):591-5. doi: 10.1016/s0190-9622(94)70221-7.
Intercellular adhesion molecule-1 (ICAM-1) is important in immune-mediated mechanisms, and its circulating form (cICAM-1) may be an indicator of immune activation. Localized scleroderma is accompanied by various immunologic abnormalities.
We investigated whether the serum level of cICAM-1 in patients with localized scleroderma was elevated and was correlated with the clinical or serologic features of this disease.
Serum cICAM-1 levels were determined by an enzyme-linked immunosorbent assay in 48 patients with localized scleroderma, in 20 patients with systemic sclerosis, and in 20 healthy control subjects.
Serum levels of cICAM-1 were significantly higher in patients with localized scleroderma than in the healthy control subjects. These levels correlated with the number of lesions, the number of involved areas, levels of antihistone antibody IgM, and levels of soluble interleukin 2 receptor.
The results suggest that immune activation may be a factor in localized scleroderma.
细胞间黏附分子-1（ICAM-1）在免疫介导机制中起重要作用，其循环形式（cICAM-1）可能是免疫激活的一个指标。局限性硬皮病伴有多种免疫异常。
我们研究局限性硬皮病患者血清cICAM-1水平是否升高，以及是否与该疾病的临床或血清学特征相关。
采用酶联免疫吸附测定法测定48例局限性硬皮病患者、20例系统性硬化症患者和20例健康对照者的血清cICAM-1水平。
局限性硬皮病患者血清cICAM-1水平显著高于健康对照者。这些水平与皮损数量、受累部位数量、抗组蛋白抗体IgM水平及可溶性白细胞介素2受体水平相关。
结果提示免疫激活可能是局限性硬皮病的一个因素。
