大肠杆菌中双链断裂引发的DNA复制：对同源重组功能的依赖性。
DNA replication triggered by double-stranded breaks in E. coli: dependence on homologous recombination functions.
作者信息
Asai T, Bates D B, Kogoma T
机构信息
Department of Cell Biology, University of New Mexico School of Medicine, Albuquerque 87131.
出版信息
Cell. 1994 Sep 23;78(6):1051-61. doi: 10.1016/0092-8674(94)90279-8.
Abstract
Homologous recombination-dependent DNA replication (RDR) of a lambda cos site-carrying plasmid is demonstrated in E. coli cells when the cells express lambda terminase that introduces a double-stranded break into the cos site. RDR occurs in normal wild-type cells if the plasmid also contains the recombination hotspot chi. Chi is dispensable when cells are induced for the SOS response or contain a recD mutation. recBC sbcA mutant cells are also capable of RDR induction. A recN mutation greatly reduces RDR in normal cells, but not in SOS-induced cells. RDR proceeds by the theta mode or rolling circle mode of DNA synthesis, yielding covalently closed circular plasmid monomers or linear plasmid multimers, respectively. Previously described inducible stable DNA replication is considered to be a special type of RDR that starts exclusively from specific sites (oriMs) on the chromosome.
摘要
当大肠杆菌细胞表达能在粘性末端位点引入双链断裂的λ末端酶时，携带λ粘性末端位点的质粒会发生同源重组依赖性DNA复制（RDR）。如果质粒还含有重组热点χ序列，RDR会在正常野生型细胞中发生。当细胞被诱导产生SOS反应或含有recD突变时，χ序列是可有可无的。recBC sbcA突变细胞也能够诱导RDR。recN突变在正常细胞中会大大降低RDR，但在SOS诱导的细胞中不会。RDR通过DNA合成的θ模式或滚环模式进行，分别产生共价闭合的环状质粒单体或线性质粒多聚体。先前描述的可诱导稳定DNA复制被认为是一种特殊类型的RDR，它仅从染色体上的特定位点（oriMs）开始。
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