成人T细胞白血病病毒1型葡萄膜炎患者中成人T细胞白血病病毒1型的亚型分析。
Subtype analysis of HTLV-1 in patients with HTLV-1 uveitis.
作者信息
Ono A, Miura T, Araki S, Yamaguchi K, Takatsuki K, Mori S, Hayami M, Mochizuki M, Watanabe T
机构信息
Department of Pathology, University of Tokyo.
出版信息
Jpn J Cancer Res. 1994 Aug;85(8):767-70. doi: 10.1111/j.1349-7006.1994.tb02945.x.
Abstract
The hypothesis that HTLV-1 uveitis, a recently identified disease entity associated with human T-cell leukemia virus type I (HTLV-1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV-1 from five patients with HTLV-1 uveitis (HU) and four with adult T-cell leukemia were phylogenetically analyzed. Our results showed that both subtypes which had been identified in Japan were associated with HU, indicating that there was no difference in pathogenicity between these phylogenetic subtypes. One of the subtypes was more frequently isolated in Okinawa than in Kyushu, suggesting a bias in the prevalence of each subtype among the inhabitants of these two areas of Japan.
摘要
人类T细胞白血病病毒I型（HTLV-1）葡萄膜炎是一种最近确认的与HTLV-1相关的疾病实体，关于该疾病由病毒的特定亚型引起这一假说得到了验证。对5例HTLV-1葡萄膜炎（HU）患者和4例成人T细胞白血病患者的HTLV-1长末端重复序列的核苷酸序列进行了系统发育分析。我们的结果表明，在日本已鉴定出的两种亚型均与HU相关，这表明这些系统发育亚型之间在致病性上没有差异。其中一种亚型在冲绳比在九州更频繁地分离出来，这表明在日本这两个地区的居民中，各亚型的流行存在偏差。
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