Dassain M, Bouché J P
Laboratoire de Microbiologie et de Génétique Moléculaire du Centre National de la Recherche Scientifique, Toulouse, France.
J Bacteriol. 1994 Oct;176(19):6143-5. doi: 10.1128/jb.176.19.6143-6145.1994.
In Escherichia coli, nucleoid separation and cell constriction remain tightly linked when division is retarded by altering the level of synthesis of the protein FtsZ. In this study, we have examined the role of the min locus, which is responsible for the inactivation of polar division sites, in the partition-septation coupling mechanism. We conclude that the coupling persists in a delta min strain and that its timing relative to replication remains dependent on the level of FtsZ synthesis. We suggest that the retarded nucleoid segregation observed in min mutants is the result of this coupling in cells with a perturbed pattern of nonpolar divisions.
在大肠杆菌中，当通过改变FtsZ蛋白的合成水平来延迟细胞分裂时，类核分离和细胞缢缩仍紧密相连。在本研究中，我们检测了负责极性分裂位点失活的min位点在分区-隔膜偶联机制中的作用。我们得出结论，这种偶联在Δmin菌株中持续存在，并且其相对于复制的时间仍然依赖于FtsZ的合成水平。我们认为，在min突变体中观察到的类核分离延迟是细胞中非极性分裂模式受到干扰时这种偶联的结果。
