Martin K A, Junker A K, Thomas E E, Van Allen M I, Friedman J M
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
J Infect Dis. 1994 Oct;170(4):991-5. doi: 10.1093/infdis/170.4.991.
In a group of 21 women counseled after exposure to chickenpox during pregnancy, 4 developed varicella despite initial studies showing that preinfection sera were varicella-zoster virus (VZV)-seropositive by fluorescent anti-membrane antibody, latex agglutination, ELISA, and VZV glycoprotein immunoblot assay. Further investigations showed that 2 of the 4 had low-titer (1/100), low-avidity, VZV-reactive IgG3 antibodies by ELISAs of preinfection sera. After chickenpox, these women developed primary-like serologic responses to VZV. Two women with high-titer (1/1600, 1/3200), high-avidity, IgG1 antibodies showed anamnestic serologic responses after reinfection. The criteria of protective VZV immunity remain ill-defined.
在一组21名在孕期接触水痘后接受咨询的女性中，尽管初始研究显示感染前血清通过荧光抗膜抗体、乳胶凝集试验、酶联免疫吸附测定（ELISA）和水痘带状疱疹病毒（VZV）糖蛋白免疫印迹试验呈VZV血清阳性，但仍有4人患了水痘。进一步调查显示，这4人中的2人在感染前血清的ELISA检测中，VZV反应性IgG3抗体滴度低（1/100）、亲和力低。感染水痘后，这些女性对VZV产生了类似初次感染的血清学反应。两名VZV特异性IgG1抗体滴度高（1/1600、1/3200）、亲和力高的女性在再次感染后出现了回忆性血清学反应。具有保护性的VZV免疫力标准仍不明确。
