Allen C M
Section of Oral and Maxillofacial Surgery and Pathology, Ohio State University, College of Dentistry.
Oral Surg Oral Med Oral Pathol. 1994 Aug;78(2):216-21. doi: 10.1016/0030-4220(94)90150-3.
Candida albicans is the most common fungal infection of the human oral mucosa, yet much remains to be understood with respect to the pathogenesis of the disease. Numerous difficulties are inherent in designing studies that use human beings as subjects. The use of various animal species in experimental contexts has helped to provide insight with respect to this condition. A variety of manipulations of the system can be performed, including altering the host immune response, the mucosal environment, or the systemic environment. In addition, organism-related factors can be examined in a more controlled setting. The information obtained from such studies could not be obtained in an in vitro situation.
白色念珠菌是人类口腔黏膜最常见的真菌感染，但关于该疾病的发病机制仍有许多有待了解之处。设计以人类为受试者的研究存在诸多内在困难。在实验环境中使用各种动物物种有助于深入了解这种情况。可以对该系统进行多种操作，包括改变宿主免疫反应、黏膜环境或全身环境。此外，可以在更可控的环境中研究与生物体相关的因素。从这类研究中获得的信息无法在体外情况下获得。
