Knedlitschek G, Noszvai-Nagy M, Meyer-Waarden H, Schimmelpfeng J, Weibezahn K F, Dertinger H
Kernforschungszentrum karlsruhe, Institut für Toxikologie, Karlsruhe, Germany.
Radiat Environ Biophys. 1994;33(2):141-7. doi: 10.1007/BF01219337.
The action on intracellular cyclic AMP (cAMP) of therapeutically used 4000-Hz electric fields was investigated and compared with 50-Hz data. Cultured mouse fibroblasts were exposed for 5 minutes to 4000-Hz sine wave internal electric fields between 3 mV/m and 30 V/m applied within culture medium. A statistically significant decrease in cellular cAMP concentration relative to unexposed cells was observed for fields higher than 10 mV/m. The drop in cAMP was most pronounced at lower field strengths (71% of controls at 30 mV/m) and tended to disappear at higher field strengths. An increase of cAMP content was observed with 50-Hz electric fields, as was also the case when 4000-Hz fields were modulated with certain low frequencies.
