Ohkuni H, Kimura Y
Exp Cell Biol. 1976;44(2):83-94. doi: 10.1159/000163102.
The increased capillary permeability in the skin of guinea pigs and rats was induced by peptidoglycan fraction (PG fraction) extracted from cell walls of group A streptococcus, but not by C-carbohydrate of streptococcal cell walls nor lipopolysaccharide of Escherichia coli and Salmonella abortus. The increased capillary permeability caused by PG fraction was also observed in germ-free rats. It was suggested that the increased capillary permeability for PG fraction might be due to the biological activity of PG fraction. The pattern of the reaction of increased capillary permeability consists of two phases: the leakage of the dye in the first phase appeared immediately after the intracutaneous injection of PG fraction, and the second phase seems to depend upon vasculitis. The increasing activity of capillary permeability to PG fraction may play an important role in inducing initial change of tissue injury by streptococcal cell walls.
从A组链球菌细胞壁提取的肽聚糖组分（PG组分）可诱导豚鼠和大鼠皮肤毛细血管通透性增加，而链球菌细胞壁的C碳水化合物、大肠杆菌和流产沙门氏菌的脂多糖则不会。在无菌大鼠中也观察到PG组分引起的毛细血管通透性增加。提示PG组分导致的毛细血管通透性增加可能归因于PG组分的生物活性。毛细血管通透性增加反应的模式包括两个阶段：第一阶段，皮内注射PG组分后染料立即渗漏，第二阶段似乎取决于血管炎。毛细血管对PG组分通透性的增加活性可能在诱导链球菌细胞壁所致组织损伤的初始变化中起重要作用。
