关于佐剂的作用机制。
On the mechanism of action of adjuvants.
作者信息
Frost P, Lance E M
出版信息
Immunology. 1978 Jul;35(1):63-8.
Abstract
Evidence is presented that one a way which adjuvants exert their effect is by initiating an enduring increase in the localization of labelled cells in draining lymphoid tissues. Agents not generally considered to be adjuvants (carbon, latex, sheep erythrocytes) but capable of altering lymphocyte recirculation are shown to prevent the induction of tolerance by soluble bovine gamma globulin (BGG). These properties fulfil the criteria for adjuvanticity as defined by Dresser (1968) and link the expression of adjuvanticity to alterations in lymphocyte circulation.
摘要
有证据表明，佐剂发挥作用的一种方式是引发引流淋巴组织中标记细胞定位的持续增加。通常不被视为佐剂的物质（碳、乳胶、绵羊红细胞）但能够改变淋巴细胞再循环，已证明它们可防止可溶性牛γ球蛋白（BGG）诱导耐受性。这些特性符合Dresser（1968年）定义的佐剂性标准，并将佐剂性的表达与淋巴细胞循环的改变联系起来。
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