al-Harbi M M, Qureshi S, Raza M, Ahmed M M, Giangreco A B, Shah A H
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Chemotherapy. 1994 Sep-Oct;40(5):337-47. doi: 10.1159/000239216.
The anticarcinogenic potential of Commiphora molmol (oleoresin) was studied in Ehrlich-solid-tumor-bearing mice. The antitumor activity of C. molmol was evaluated from the total count and viability of Ehrlich solid tumor cells and their nucleic acid, protein, malondialdehyde and glutathione levels at the end of 25 and 50 days of treatment. Furthermore, observations of animal survival rate and measurements of the tumor and body weight were made. The Ehrlich solid tumors were also evaluated for histopathological changes. Treatment with C. molmol (250 and 500 mg/kg/day) was found to be cytotoxic in Ehrlich solid tumors cells. The antitumor potential of C. molmol was comparable to the standard cytotoxic drug cyclophosphamide. This effect of C. molmol was less pronounced after 50 days of treatment. The present study confirmed the cytotoxic and anticarcinogenic potential of C. molmol. Further studies are warranted to explore its mode of action and safety for medicinal use in cancer therapy.
在接种艾氏实体瘤的小鼠中研究了没药（油树脂）的抗癌潜力。在治疗25天和50天结束时，通过艾氏实体瘤细胞的总数、活力及其核酸、蛋白质、丙二醛和谷胱甘肽水平来评估没药的抗肿瘤活性。此外，还观察了动物存活率，并测量了肿瘤和体重。对艾氏实体瘤也进行了组织病理学变化评估。发现用没药（250和500毫克/千克/天）治疗对艾氏实体瘤细胞具有细胞毒性。没药的抗肿瘤潜力与标准细胞毒性药物环磷酰胺相当。在治疗50天后，没药的这种作用不太明显。本研究证实了没药的细胞毒性和抗癌潜力。有必要进一步研究以探索其作用方式和在癌症治疗中药用的安全性。
