Gonzalez S I, Suescun M O, Rulli S B, Estivariz F, Calandra R S
Instituto de Biología y Medicina Experimental, Buenos Aires, República Argentina.
Int J Androl. 1994 Jun;17(3):143-8. doi: 10.1111/j.1365-2605.1994.tb01234.x.
The stimulatory effect of prolactin on sexual accessory glands is well established, though the mechanism of trophic action remains poorly understood. We have therefore assessed the effect of high levels of prolactin on ornithine decarboxylase activity and polyamine content in seminal vesicles (SV) of adult rats. Hyperprolactinaemia was induced by implantation of tissue fragments of a prolactin-secreting tumour 7315a, and the rats killed at 35 days post-inoculation. Serum levels of prolactin were increased significantly (p < 0.001) in tumour-bearing rats. Levels of testosterone in serum were reduced markedly, whereas LH levels remained unchanged. SV weight in the experimental group was not significantly different from that in the corresponding control group. A clear increase in ornithine decarboxylase activity of SV was observed (p < 0.001) in the hyperprolactinaemic rats. However, there was no change in the polyamine content of SV in tumour-bearing rats, compared to the control group. These results indicate that ornithine decarboxylase activity in SV of adult rats is regulated mainly by prolactin. This experimental model may be useful for identification of some of the events involved in the trophic action of prolactin.
催乳素对性附属腺的刺激作用已得到充分证实，但其营养作用机制仍知之甚少。因此，我们评估了高水平催乳素对成年大鼠精囊（SV）中鸟氨酸脱羧酶活性和多胺含量的影响。通过植入分泌催乳素的肿瘤7315a组织片段诱导高催乳素血症，并在接种后35天处死大鼠。荷瘤大鼠血清催乳素水平显著升高（p < 0.001）。血清睾酮水平显著降低，而促黄体生成素水平保持不变。实验组的精囊重量与相应对照组无显著差异。在高催乳素血症大鼠中观察到精囊鸟氨酸脱羧酶活性明显增加（p < 0.001）。然而，与对照组相比，荷瘤大鼠精囊中的多胺含量没有变化。这些结果表明，成年大鼠精囊中鸟氨酸脱羧酶活性主要受催乳素调节。该实验模型可能有助于识别催乳素营养作用中涉及的一些事件。
