人类白细胞抗原C基因座上的“沉默”等位基因。
"Silent" alleles at the HLA-C locus.
作者信息
Ferrara G, Tosi R, Longo A, Castellani A, Viviani C, Carminati G
出版信息
J Immunol. 1978 Aug;121(2):731-5.
PMID:79614
Abstract
Defined specificities of the HLA-C locus possess a significantly lower immunogenicity as compared with the HLA-A and HLA-B specificities. HLA-C "blanks" are not immunogenic at all. Among the possible explanations, the most likely one appears to be a low phenotypic expression of these alleles. C locus antigens as a whole are thus likely to be of minor relevance in donor/recipient matching for transplantation.
摘要
与HLA - A和HLA - B特异性相比，HLA - C位点的特定特异性具有显著更低的免疫原性。HLA - C“空白”根本没有免疫原性。在可能的解释中，最有可能的似乎是这些等位基因的低表型表达。因此，C位点抗原作为一个整体在移植供体/受体匹配中可能不太重要。
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