Liles J H, Flecknell P A
Comparative Biology Center, Medical School, Newcastle upon Tyne, UK.
J Vet Pharmacol Ther. 1994 Aug;17(4):284-90. doi: 10.1111/j.1365-2885.1994.tb00247.x.
Rats underwent a midline laparotomy and received buprenorphine, buprenorphine together with carprofen, flunixin or carprofen alone while a control group received saline. Food and water intakes and body weight were reduced following surgery in the saline control group. The degree of depression of these variables was significantly reduced by the administration of either buprenorphine or carprofen. In all groups of rats locomotor activity was depressed following surgery. Analgesic administration had little influence on these changes in activity, although administration of two doses of buprenorphine (0.05 mg/kg, 9 h interval) reduced the degree of depression in comparison to the saline control group. If the depression in food and water consumption is related to the presence of post-operative pain, then these findings suggest that analgesics should be administered to rats following surgical procedures.
大鼠接受了正中剖腹术，并分别接受丁丙诺啡、丁丙诺啡与卡洛芬联用、氟尼辛或单独使用卡洛芬，而对照组接受生理盐水。生理盐水对照组术后食物和水摄入量以及体重均下降。给予丁丙诺啡或卡洛芬可显著减轻这些变量的降低程度。所有大鼠组术后运动活动均受到抑制。镇痛药物给药对这些活动变化影响不大，不过与生理盐水对照组相比，给予两剂丁丙诺啡（0.05毫克/千克，间隔9小时）可减轻抑制程度。如果食物和水消耗的减少与术后疼痛的存在有关，那么这些发现表明，术后应给大鼠使用镇痛药。
