丙型肝炎病毒在细胞培养中的多轮感染及α和β干扰素的抑制作用。
Multicycle infection of hepatitis C virus in cell culture and inhibition by alpha and beta interferons.
作者信息
Shimizu Y K, Yoshikura H
机构信息
Department of Viral Diseases and Vaccine Control, National Institute of Health, Tokyo.
出版信息
J Virol. 1994 Dec;68(12):8406-8. doi: 10.1128/JVI.68.12.8406-8408.1994.
We previously reported that a clone of a human lymphocytic cell line, HPBMa clone 10-2, supports the genome replication of hepatitis C virus (HCV). In the present study, the multicycle transmission of HCV from infected cells to new cells was demonstrated by coculture with drug-resistant cells as recipients; i.e., the system was proved productive for infectious HCV. Inhibition of viral replication by alpha and beta interferons was observed.
我们之前报道过，一种人类淋巴细胞系克隆体，HPBMa克隆体10 - 2，能够支持丙型肝炎病毒（HCV）的基因组复制。在本研究中，通过与作为受体的耐药细胞共培养，证明了HCV从受感染细胞到新细胞的多轮传播；也就是说，该系统被证明对有传染性的HCV具有生产性。观察到α和β干扰素对病毒复制的抑制作用。
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