帕金森病患者脑脊液中谷胱甘肽和α-生育酚的还原型与氧化型：左旋多巴治疗前后的比较

Reduced and oxidized forms of glutathione and alpha-tocopherol in the cerebrospinal fluid of parkinsonian patients: comparison between before and after L-dopa treatment.

作者信息

Tohgi H, Abe T, Saheki M, Hamato F, Sasaki K, Takahashi S

机构信息

Department of Neurology, Iwate Medical University, Morioka, Japan.

出版信息

Neurosci Lett. 1995 Jan 16;184(1):21-4. doi: 10.1016/0304-3940(94)11158-f.

DOI:10.1016/0304-3940(94)11158-f

PMID:7739798

Abstract

In the cerebrospinal fluid of untreated patients with Parkinson's disease (PD) the concentrations of reduced glutathione (GSH) and alpha-tocopherol (alpha-TOH) were unaltered but the concentration of oxidized glutathione (glutathione disulfide, GSSG) (P < 0.001), the GSSG/GSH ratio (P < 0.06), alpha-tocopherol quinone (alpha-TQ) (P < 0.001), and the alpha-TQ/alpha-TOH ratio (P < 0.01) were reduced significantly. In L-dopa-treated patients, the concentrations of GSH, GSSG, and the alpha-TQ concentration and the alpha-TQ/alpha-TOH ratio (P < 0.05) increased compared with untreated PD patients. These results suggest that oxidation of GSH and alpha-TOH is decreased in untreated PD patients, but is activated to a control level or more after L-dopa treatment.

摘要

在未经治疗的帕金森病（PD）患者的脑脊液中，还原型谷胱甘肽（GSH）和α-生育酚（α-TOH）的浓度未发生改变，但氧化型谷胱甘肽（谷胱甘肽二硫化物，GSSG）的浓度（P < 0.001）、GSSG/GSH比值（P < 0.06）、α-生育酚醌（α-TQ）（P < 0.001）以及α-TQ/α-TOH比值（P < 0.01）均显著降低。在接受左旋多巴治疗的患者中，与未经治疗的PD患者相比，GSH、GSSG的浓度以及α-TQ浓度和α-TQ/α-TOH比值（P < 0.05）均有所升高。这些结果表明，未经治疗的PD患者中GSH和α-TOH的氧化作用减弱，但在左旋多巴治疗后被激活至对照水平或更高。