Dutka-Malen S, Blaimont B, Wauters G, Courvalin P
Unité des Agents Antibactériens, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.
Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7. doi: 10.1128/AAC.38.7.1675.
Enterococcus gallinarum BM4231 and Enterococcus casseliflavus BM4232, isolated from the feces of a patient under oral therapy with vancomycin, were resistant to high levels of vancomycin (MICs of > 256 micrograms/ml) and teicoplanin (MICs of 128 and 64 micrograms/ml, respectively). This phenotype is new for these bacterial species that are naturally resistant to low levels of vancomycin and appears to be due to in vivo acquisition of plasmid pIP218 carrying the vanA gene cluster.
从一名接受万古霉素口服治疗患者的粪便中分离出的鹑鸡肠球菌BM4231和格氏肠球菌BM4232，对高水平的万古霉素（最低抑菌浓度>256微克/毫升）和替考拉宁（最低抑菌浓度分别为128和64微克/毫升）耐药。对于这些天然对低水平万古霉素耐药的细菌物种而言，这种表型是新出现的，似乎是由于在体内获得了携带vanA基因簇的质粒pIP218。
