酿酒酵母的LTE1是一个由1435个密码子组成的开放阅读框，与鸟嘌呤核苷酸释放因子具有序列相似性。
LTE1 of Saccharomyces cerevisiae is a 1435 codon open reading frame that has sequence similarities to guanine nucleotide releasing factors.
作者信息
Keng T, Clark M W, Storms R K, Fortin N, Zhong W, Ouellette B F, Barton A B, Kaback D B, Bussey H
机构信息
Biology Department, McGill University, Montreal, Canada.
出版信息
Yeast. 1994 Jul;10(7):953-8. doi: 10.1002/yea.320100710.
The DNA sequence of the LTE1 gene on the left arm of chromosome I of Saccharomyces cerevisiae has been determined. The LTE1 open reading frame comprises 4305 bp that can be translated into 1435 amino acid residues. The position of this open reading frame corresponds well to that of a 4.7 kb transcript that has been mapped to this position. The derived amino acid sequence has significant similarities to the amino acid sequence of the guanine nucleotide releasing factor isolated from a rat brain library. The carboxy-terminus of the LTE1 protein also shows similarities to other guanine nucleotide exchange factors of the S. cerevisiae CDC25 family.
已经测定了酿酒酵母1号染色体左臂上LTE1基因的DNA序列。LTE1开放阅读框包含4305个碱基对，可翻译成1435个氨基酸残基。该开放阅读框的位置与已定位到该位置的4.7 kb转录本的位置非常吻合。推导的氨基酸序列与从大鼠脑文库中分离出的鸟嘌呤核苷酸释放因子的氨基酸序列有显著相似性。LTE1蛋白的羧基末端也与酿酒酵母CDC25家族的其他鸟嘌呤核苷酸交换因子有相似性。
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