2'-脱氧-2'-氟核糖苷对雪貂甲型和乙型流感病毒的疗效。
Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets.
作者信息
Jakeman K J, Tisdale M, Russell S, Leone A, Sweet C
机构信息
School of Biological Sciences, Microbial Molecular Genetics and Cell Biology Research Group, University of Birmingham, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7. doi: 10.1128/AAC.38.8.1864.
Abstract
Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. Replication of virus in the lower respiratory tract was also reduced > 100-fold, but three doses were required to prevent replication in the lungs. In ferrets infected with influenza B virus, single-dose treatment (40 mg/kg given intraperitoneally) produced a similar but reduced response in comparison with that in ferrets infected with influenza A virus, indicating that dosing was not optimal for this virus.
摘要
雪貂感染甲型流感病毒1小时后，用2'-脱氧-2'-氟鸟苷或其前药2,6-二氨基嘌呤-2'-氟核糖苷进行单剂量治疗（腹腔注射5至40毫克/千克体重），可显著抑制上呼吸道病毒复制，从而减轻发热和鼻炎症。下呼吸道病毒复制也减少了100倍以上，但需要三剂才能防止肺部病毒复制。在感染乙型流感病毒的雪貂中，单剂量治疗（腹腔注射40毫克/千克）与感染甲型流感病毒的雪貂相比，产生了相似但减弱的反应，表明该剂量对这种病毒并非最佳。
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