Abu-Shakra M, Smythe H, Lewtas J, Badley E, Weber D, Keystone E
Wellesley Hospital, Toronto, Ontario, Canada.
Arthritis Rheum. 1994 Dec;37(12):1798-803. doi: 10.1002/art.1780371214.
To compare outcome in patients with polyarteritis nodosa (PAN) and patients with Churg-Strauss syndrome (CSS) followed up at a single center.
A retrospective data review of 13 patients with PAN and 12 patients with CSS who were followed up at a vasculitis clinic. Outcome measures included a global damage index, disability and pain dimensions of the Health Assessment Questionnaire, and mortality rate.
Compared with patients with CSS, patients with PAN had a significantly higher mean damage index score (5.15 versus 2.42; P = 0.011), a higher disability score (1.09 versus 0.16; P = 0.007), and a higher pain score (1.04 versus 0.01; P = 0.017). Patients with PAN had more relapses (relative risk = 5.07; P < 0.000) and a higher mortality rate (31%) compared with patients with CSS (8%).
PAN and CSS differ in their morbidity and mortality; therefore, they should be considered as distinct clinical entities.
比较在单一中心随访的结节性多动脉炎（PAN）患者和变应性肉芽肿性血管炎（CSS）患者的预后。
对在血管炎门诊随访的13例PAN患者和12例CSS患者进行回顾性数据审查。结局指标包括总体损伤指数、健康评估问卷的残疾和疼痛维度以及死亡率。
与CSS患者相比，PAN患者的平均损伤指数得分显著更高（5.15对2.42；P = 0.011），残疾得分更高（1.09对0.16；P = 0.007），疼痛得分更高（1.04对0.01；P = 0.017）。与CSS患者（8%）相比，PAN患者有更多的复发（相对风险 = 5.07；P < 0.000）和更高的死亡率（31%）。
PAN和CSS在发病率和死亡率方面存在差异；因此，它们应被视为不同的临床实体。
