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暴露于乳链菌肽的单核细胞增生李斯特氏菌细胞中生物能量参数与细胞死亡的相关性

Correlation of bioenergetic parameters with cell death in Listeria monocytogenes cells exposed to nisin.

作者信息

Winkowski K, Bruno M E, Montville T J

机构信息

Department of Food Science, New Jersey Agricultural Experiment Station, Cook College, Rutgers, State University of New Jersey, New Brunswick 08903.

出版信息

Appl Environ Microbiol. 1994 Nov;60(11):4186-8. doi: 10.1128/aem.60.11.4186-4188.1994.

DOI:10.1128/aem.60.11.4186-4188.1994
PMID:7993099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC201958/
Abstract

In Listeria monocytogenes, nisin induced ATP efflux, reduced the intracellular ATP concentration within 1 min, and dissipated the proton motive force within 2 min. Efflux accounted for only 20% of the ATP depletion, suggesting that ATP hydrolysis also occurred. ATP efflux depended on nisin concentration and followed saturation kinetics. These results suggest that nisin breaches the membrane permeability barrier in a manner more consistent with pore formation than with a nonspecific detergent-like membrane destabilization.

摘要

在单核细胞增生李斯特菌中，乳酸链球菌素可诱导ATP流出，在1分钟内降低细胞内ATP浓度，并在2分钟内耗散质子动力。流出仅占ATP消耗的20%，这表明也发生了ATP水解。ATP流出取决于乳酸链球菌素的浓度，并遵循饱和动力学。这些结果表明，乳酸链球菌素破坏膜通透性屏障的方式更符合孔形成，而不是非特异性洗涤剂样膜去稳定化。

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本文引用的文献

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Common mechanistic action of bacteriocins from lactic Acid bacteria.乳酸菌细菌素的常见作用机制。
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Pediocin PA-1, a bacteriocin from Pediococcus acidilactici PAC1.0, forms hydrophilic pores in the cytoplasmic membrane of target cells.片球菌素PA-1是一种来自嗜酸乳杆菌PAC1.0的细菌素，可在靶细胞的细胞质膜上形成亲水性孔道。
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Kinetic studies of the action of lactacin F, a bacteriocin produced by Lactobacillus johnsonii that forms poration complexes in the cytoplasmic membrane.对乳酸乳球菌素F作用的动力学研究，乳酸乳球菌素F是由约氏乳杆菌产生的一种细菌素，可在细胞质膜中形成孔道复合物。
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FEBS Lett. 1989 Feb 13;244(1):99-102. doi: 10.1016/0014-5793(89)81171-8.