同卵双胞胎1型糖尿病的免疫学研究。
Immunological studies on type 1 diabetes in identical twins.
作者信息
Peakman M, Leslie R D, Vergani D
机构信息
Department of Immunology, King's College School of Medicine and Dentistry, London.
出版信息
Arch Dis Child. 1993 Jul;69(1):97-9. doi: 10.1136/adc.69.1.97.
Abstract
Diabetes is a multifactorial disease, the pathogenesis of which involves participation of the host immune system in beta cell destruction. Studies on identical twins offer the opportunity to define genetic and non-genetic factors which may contribute to susceptibility to the disease. Our own work indicates that the number and nature, as well as the intensity and persistence of immune abnormalities of cellular and humoral immune responses can be powerful predictors of the disease and also identify twins who have a degree of protection from the disease.
摘要
糖尿病是一种多因素疾病，其发病机制涉及宿主免疫系统参与β细胞破坏。对同卵双胞胎的研究提供了确定可能导致疾病易感性的遗传和非遗传因素的机会。我们自己的研究表明，细胞免疫和体液免疫反应的免疫异常的数量、性质以及强度和持续性可以成为该疾病的有力预测指标，还能识别出对该疾病有一定抵抗力的双胞胎。
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