患有轻微脑功能障碍儿童对哌甲酯和咖啡因的个体反应。
Individual responses to methylphenidate and caffeine in children with minimal brain dysfunction.
作者信息
Garfinkel B D, Webster C D, Sloman L
机构信息
Department of Psychiatry, Hospital for Sick Children, Toronto, ON.
出版信息
Can Med Assoc J. 1975 Oct 18;113(8):729-32.
Eight children with minimal brain dysfunction were studied for their individual responses to two stimulant medications--methylphenidate hydrochloride and caffeine citrate. Four types of behavioural responses were observed in the double-blind crossover experiment: four children responded favourably to both psychostimulants, one responded to methylphenidate alone and two responded to the placebo. The behaviour of one child deteriorated while he was taking methylphenidate and caffeine. In general, methylphenidate was superior to caffeine in diminishing hyperactive and aggressive behaviour. It is apparent that such stimulant medication exerts its therapeutic effects in these two areas primarily and would therefore be useful as one aspect of a complete treatment program for children with this syndrome.
对八名患有轻微脑功能障碍的儿童针对两种刺激性药物——盐酸哌甲酯和枸橼酸咖啡因的个体反应进行了研究。在双盲交叉实验中观察到四种行为反应类型：四名儿童对两种精神兴奋剂均反应良好，一名仅对哌甲酯有反应，两名对安慰剂有反应。一名儿童在服用哌甲酯和咖啡因时行为恶化。总体而言，在减少多动和攻击性行为方面，哌甲酯优于咖啡因。显然，此类刺激性药物主要在这两个方面发挥治疗作用，因此可作为该综合征儿童完整治疗方案的一个方面。
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