细菌及细菌产物的抗肿瘤活性：脂磷壁酸增强细菌的肿瘤保护作用。

Antitumor activity of bacteria and bacterial products: enhancement of the tumor-protective effect of bacteria by lipoteichoic acid.

作者信息

Keller R, Keist R, Gustafson J E

机构信息

Department of Pathology, University Hospital, University of Zurich, Switzerland.

出版信息

Cancer Lett. 1994 Jul 15;82(1):99-104. doi: 10.1016/0304-3835(94)90152-x.

DOI:10.1016/0304-3835(94)90152-x

PMID:8033076

Abstract

The ability of some microbial agents and/or their products to affect local tumor growth was assessed in the D-12 DA rat ascites tumor model. Various bacteria and bacterial products markedly enhanced tumor resistance when injected i.p. several days before tumor cell challenge. The tumor-protective effect of these compounds was amplified further by lipoteichoic acid (LTA) inoculated i.p. a few days after tumor cell challenge. Under these conditions, the majority of animals did not exhibit progressive tumor growth.

摘要

在D - 12 DA大鼠腹水肿瘤模型中评估了某些微生物制剂和/或其产物影响局部肿瘤生长的能力。在肿瘤细胞攻击前几天腹腔注射各种细菌和细菌产物时，可显著增强肿瘤抵抗力。在肿瘤细胞攻击后几天腹腔接种脂磷壁酸（LTA），这些化合物的肿瘤保护作用会进一步增强。在这些条件下，大多数动物并未出现肿瘤的进行性生长。