Fullerton A, Broby-Johansen U, Agner T
Department of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen.
Contact Dermatitis. 1994 Apr;30(4):222-5. doi: 10.1111/j.1600-0536.1994.tb00648.x.
Because of their ability to impair the skin barrier function, detergents constitute a major risk factor for the development of irritant contact dermatitis. Sodium lauryl sulphate (SLS) is a commonly used detergent for experimental studies within the area of irritant contact dermatitis. In the present study, penetration of S35-labelled SLS was studied in an in vitro model using human cadaver skin. The investigations showed that SLS is capable of permeating the skin barrier when applied under occlusion. SLS could be detected in the dermis and the amount of SLS found here was shown to depend on the dose of SLS applied on the skin. Penetration of SLS continued after removal of the SLS applied as a patch test on the skin surface. Considerable inter-individual variation in the penetration of SLS was demonstrated between different donors.
由于具有损害皮肤屏障功能的能力，洗涤剂是刺激性接触性皮炎发生的主要危险因素。月桂醇硫酸酯钠（SLS）是刺激性接触性皮炎领域实验研究中常用的洗涤剂。在本研究中，使用人体尸体皮肤的体外模型研究了S35标记的SLS的渗透情况。研究表明，当在封闭条件下应用时，SLS能够穿透皮肤屏障。在真皮中可检测到SLS，且此处发现的SLS量取决于施用于皮肤的SLS剂量。在去除作为斑贴试验施用于皮肤表面的SLS后，SLS的渗透仍在继续。不同供体之间SLS的渗透存在相当大的个体差异。
