Emilson A, Lindberg M, Forslind B
EDRG, Department of Medical Biophysics, Karolinska Institute, Stockholm, Sweden.
Acta Derm Venereol. 1993 Jun;73(3):203-7. doi: 10.2340/0001555573203207.
Irritant contact dermatitis is a major problem in dermatology. One important group of substances causing irritant dermatitis is detergents. Exposure of the skin to detergents is frequent in both work and domestic environments. In the present paper we have studied how the penetration through the skin, and thus the effect, of the detergent sodium lauryl sulfate (SLS) is altered when the temperature is raised from 22 degrees C to 40 degrees C or 60 degrees C. We found that the penetration of sodium lauryl sulfate increased with increasing temperature. When comparing the increased penetration of sodium lauryl sulfate with the change in NiCl penetration at the same temperatures, we found that the increase in penetration was more pronounced for the detergent. This implies that the detergent also had a different effect on the structure and function of the epidermal barrier itself. The results underline the importance of choosing the right (low) temperature when working with detergent solutions to reduce the risk of developing irritant contact reactions.
刺激性接触性皮炎是皮肤科的一个主要问题。导致刺激性皮炎的一类重要物质是洗涤剂。在工作和家庭环境中，皮肤经常接触洗涤剂。在本论文中，我们研究了将温度从22摄氏度升高到40摄氏度或60摄氏度时，洗涤剂月桂醇硫酸酯钠（SLS）透过皮肤的情况以及由此产生的效果是如何变化的。我们发现，月桂醇硫酸酯钠的渗透率随温度升高而增加。当比较月桂醇硫酸酯钠渗透率的增加与相同温度下氯化镍渗透率的变化时，我们发现洗涤剂的渗透率增加更为明显。这意味着洗涤剂对表皮屏障本身的结构和功能也有不同的影响。这些结果强调了在使用洗涤剂溶液时选择合适（较低）温度以降低发生刺激性接触反应风险的重要性。
