Noguchi A, Hayashi J, Nakashima K, Hirata M, Ikematsu H, Kashiwagi S
Department of General Medicine, Kyushu University Hospital, Japan.
J Infect. 1994 Mar;28(2):141-50. doi: 10.1016/s0163-4453(94)95560-3.
In Okinawa, Japan 1261 hepatitis B surface antigen (HBsAg) carriers were investigated for clinical differences among HBsAg subtypes. Among the 854 for whom they could be determined, subtype adw was found in 604 (70.7%), adr in 232 (27.2%) and others in 18 (2.1%). The overall prevalence of hepatitis B e antigen (HBeAg) was significantly lower in subtype adw (11.9%) than in adr (17.7%) (P < 0.01). The mean age of HBeAg-positive carriers was significantly lower in adw (20.4 years) than in adr (26.9 years) (P < 0.05). Seroconversion from HBeAg to antibody to HBeAg (anti-HBe) occurred in 43 carriers. The seroconversion rate was higher in adw (43.1%) than in adr (29.3%) and the seroconversion age was younger in adw (22.7 years) than in adr (27.9 years). These results suggest that carriers with subtype adw tend to seroconvert from HBeAg to anti-HBe at a higher rate and a younger age than do those with adr. HBsAg subtypes may be closely associated with the HBeAg/anti-HBe status.
在日本冲绳，对1261名乙型肝炎表面抗原（HBsAg）携带者进行了研究，以探讨HBsAg亚型之间的临床差异。在能够确定亚型的854名携带者中，发现adw亚型有604名（70.7%），adr亚型有232名（27.2%），其他亚型有18名（2.1%）。乙型肝炎e抗原（HBeAg）的总体流行率在adw亚型（11.9%）中显著低于adr亚型（17.7%）（P<0.01）。HBeAg阳性携带者的平均年龄在adw亚型（20.4岁）中显著低于adr亚型（26.9岁）（P<0.05）。43名携带者发生了从HBeAg到HBeAg抗体（抗-HBe）的血清学转换。血清学转换率在adw亚型（43.1%）中高于adr亚型（29.3%），血清学转换年龄在adw亚型（22.7岁）中比adr亚型（27.9岁）小。这些结果表明，与adr亚型携带者相比，adw亚型携带者倾向于以更高的比率和更年轻的年龄从HBeAg转换为抗-HBe。HBsAg亚型可能与HBeAg/抗-HBe状态密切相关。
