Hayashi J, Kashiwagi S, Ikematsu H, Nomura H, Kajiyama W, Noguchi A, Ikeda K
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
Microbiol Immunol. 1988;32(8):843-50. doi: 10.1111/j.1348-0421.1988.tb01445.x.
We investigated sex- and age-specific prevalences of hepatitis B e antigen (HBeAg) and antibody to HBeAg (anti-HBe) in 1,163 carriers of hepatitis B surface antigen (HBsAg) in Okinawa, Japan, and followed them up for longer than one year in correlation with liver function abnormalities. Elevated serum transaminase levels were found in 160 (13.8%) of them. The prevalence of liver function abnormalities was significantly higher in male carriers (127/690, 18.4%) than in female carriers (33/473, 7.0%) at a P value of 0.001. In asymptomatic carriers, the prevalence of HBeAg was 13.2% and that of anti-HBe 80.0%, significantly different from 41.9% and 54.4%, respectively, in carriers with elevated transaminase levels (P less than 0.001). In asymptomatic carriers, the mean age of HBeAg-positive carriers was 16.7 years which was much lower than the 22.8 years in carriers with liver function abnormalities. The prevalence of elevated transaminase levels was significantly higher in carriers with HBeAg than in those with anti-HBe (33.8% vs. 9.7%, P less than 0.001). Based on these results, the prolonged positivity for serum HBeAg would qualify as a predictor for deteriorating liver function among HBsAg carriers.
我们调查了日本冲绳1163名乙型肝炎表面抗原（HBsAg）携带者中乙型肝炎e抗原（HBeAg）和乙型肝炎e抗原抗体（抗-HBe）的性别和年龄特异性流行率，并对他们进行了一年以上的随访，同时观察其与肝功能异常的相关性。其中160人（13.8%）血清转氨酶水平升高。男性携带者肝功能异常的流行率（127/690，18.4%）显著高于女性携带者（33/473，7.0%），P值为0.001。在无症状携带者中，HBeAg的流行率为13.2%，抗-HBe的流行率为80.0%，与转氨酶水平升高的携带者分别为41.9%和54.4%有显著差异（P<0.001）。在无症状携带者中，HBeAg阳性携带者的平均年龄为16.7岁，远低于肝功能异常携带者的22.8岁。HBeAg携带者转氨酶水平升高的流行率显著高于抗-HBe携带者（33.8%对9.7%，P<0.001）。基于这些结果，血清HBeAg的长期阳性可作为HBsAg携带者肝功能恶化的预测指标。
