Smoller B R, Van de Rijn M, Lebrun D, Warnke R A
Department of Pathology, Stanford University Medical Center, CA 94305.
Br J Dermatol. 1994 Jul;131(1):28-31. doi: 10.1111/j.1365-2133.1994.tb08453.x.
Trichoepitheliomas (TE) are benign follicular neoplasms which are frequently confused with basal cell carcinomas (BCC). It is important to distinguish these entities precisely, as the treatments and prognoses are different. To this end, we stained a series of formalin-fixed, paraffin-embedded specimens of unequivocal TE and BCC with antibodies directed against bcl-2, an oncogene associated with programmed cell death, and known to be overexpressed in some malignant tumours. The TE showed staining of tumour cells limited to the outermost layer of the proliferation. The BCC tumour cells demonstrated diffuse staining throughout the tumour nodules. This difference in staining pattern was then applied to more equivocal cases, and seemed clearly to separate the entities. The observed findings may prove to be of diagnostic help in distinguishing borderline cases, and also offer some possible explanations for the biological differences between these neoplasms.
毛发上皮瘤（TE）是一种良性毛囊肿瘤，常与基底细胞癌（BCC）混淆。准确区分这些实体很重要，因为治疗方法和预后不同。为此，我们用针对bcl-2的抗体对一系列明确诊断的TE和BCC的福尔马林固定、石蜡包埋标本进行染色，bcl-2是一种与程序性细胞死亡相关的癌基因，已知在一些恶性肿瘤中过度表达。TE显示肿瘤细胞的染色仅限于增殖的最外层。BCC肿瘤细胞在整个肿瘤结节中呈弥漫性染色。然后将这种染色模式的差异应用于更多不明确的病例，似乎能清楚地区分这些实体。观察到的结果可能有助于诊断边界病例，也为这些肿瘤之间的生物学差异提供了一些可能的解释。
