多环芳烃暴露工人血红蛋白中苯并(a)芘二醇环氧化物加合物的决定因素。
Determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin in workers exposed to polycyclic aromatic hydrocarbons.
作者信息
Ferreira Júnior M F, Tas S, dell'Omo M, Goormans G, Buchet J P, Lauwerys R
机构信息
Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium.
出版信息
Occup Environ Med. 1994 Jul;51(7):451-5. doi: 10.1136/oem.51.7.451.
OBJECTIVE
The aim was to assess the determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin (BaPDE-Hb) in workers exposed to polycyclic aromatic hydrocarbons (PAHs).
METHODS
This was a study of the correlations between the concentrations of PAHs in air, 1-hydroxyprene in urine, and BaPDE-Hb adduct concentration in the blood in 206 men working in steel foundries and one graphite electrode producing plant, taking into consideration confounding factors such as smoking and dietary habits.
RESULTS
BaPDE-Hb adduct concentration was correlated (r = 0.26; p = 0.0002) with the airborne PAH concentration and was influenced by tobacco consumption but not by dietary habits. Benzo(a)-pyrene concentration in air, 1-hydroxypyrene concentration in urine, and duration of exposure to PAHs were not associated with the adduct concentration.
CONCLUSION
Although environmental exposure to PAHs was statistically associated with BaPDE-Hb adduct concentration, differences between individual subjects in the metabolism of benzo(a)pyrene probably play an important part in determining the amount of BaPDE-Hb adducts formed.
目的
旨在评估多环芳烃（PAHs）暴露工人血红蛋白中苯并（a）芘二醇环氧化物加合物（BaPDE-Hb）的决定因素。
方法
本研究对206名在钢铁铸造厂和一家石墨电极生产厂工作的男性工人的空气中PAHs浓度、尿中1-羟基芘浓度和血液中BaPDE-Hb加合物浓度之间的相关性进行了研究，同时考虑了吸烟和饮食习惯等混杂因素。
结果
BaPDE-Hb加合物浓度与空气中PAH浓度相关（r = 0.26；p = 0.0002），并受烟草消费影响，但不受饮食习惯影响。空气中苯并（a）芘浓度、尿中1-羟基芘浓度和PAHs暴露持续时间与加合物浓度无关。
结论
尽管环境中PAHs暴露与BaPDE-Hb加合物浓度在统计学上相关，但个体间苯并（a）芘代谢的差异可能在决定形成的BaPDE-Hb加合物数量方面起重要作用。
Zotero 插件