Suppr超能文献

Endogenous synthesis of N-methylnorsalsolinol in rat brain during in vivo microdialysis with epinine.

作者信息

Kajita M, Niwa T, Maruyama W, Nakahara D, Takeda N, Yoshizumi H, Tatematsu A, Watanabe K, Naoi M, Nagatsu T

机构信息

Department of Pediatrics, Nagoya University School of Medicine, Japan.

出版信息

J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):263-9. doi: 10.1016/0378-4347(94)00019-0.

DOI:10.1016/0378-4347(94)00019-0
PMID:8044287
Abstract

The in vivo metabolic pathway for the synthesis of N-methylnorsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was studied in the rat brain. N-Methyldopamine (epinine) was perfused at the striatum of the rat brain by in vivo microdialysis. N-Methylnorsalsolinol (NMNSAL) was identified in the brain dialysate after epinine perfusion using gas chromatography-selected-ion monitoring mass spectrometry (GC-SIM-MS). We demonstrated that NMNSAL could be synthesized from epinine with an aldehyde by the Piclet-Spengler condensation reaction in the rat brain.

摘要

相似文献

1
Endogenous synthesis of N-methylnorsalsolinol in rat brain during in vivo microdialysis with epinine.
J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):263-9. doi: 10.1016/0378-4347(94)00019-0.
2
Presence of N-methyldopamine in parkinsonian and normal human brains.
J Chromatogr. 1993 Mar 5;613(1):1-8. doi: 10.1016/0378-4347(93)80190-f.
3
Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography-mass spectrometry.
J Chromatogr. 1992 Jul 1;578(1):109-15. doi: 10.1016/0378-4347(92)80231-e.
4
N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.
J Neurochem. 1992 Aug;59(2):395-400. doi: 10.1111/j.1471-4159.1992.tb09384.x.
5
Detection of 1-phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline in human brain by gas chromatography-tandem mass spectrometry.
J Chromatogr B Biomed Appl. 1995 Jul 21;669(2):345-51. doi: 10.1016/0378-4347(95)00106-s.
6
Determination of 1-methyl-1,2,3,4-tetrahydroisoquinoline in mouse brain after treatment with haloperidol by gas chromatography-selected ion monitoring.
J Chromatogr B Biomed Sci Appl. 1999 Aug 6;731(1):53-8. doi: 10.1016/s0378-4347(99)00187-5.
7
Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.
Biochem Biophys Res Commun. 1987 Apr 29;144(2):1084-9. doi: 10.1016/s0006-291x(87)80075-x.
8
Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.
Biochem Biophys Res Commun. 1991 Jun 14;177(2):603-9. doi: 10.1016/0006-291x(91)91831-v.
9
Endogenous synthesis of N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of N-methylisoquinolinium ion, in the brains of primates with parkinsonism after systemic administration of 1,2,3,4-tetrahydroisoquinoline.
J Chromatogr. 1990 Nov 30;533:145-51. doi: 10.1016/s0378-4347(00)82195-7.
10
Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain.
Biochem Biophys Res Commun. 1986 Oct 15;140(1):448-54. doi: 10.1016/0006-291x(86)91111-3.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验