Nellen D, Affolter M, Basler K
Zoologisches Institut Universität Zürich, Switzerland.
Cell. 1994 Jul 29;78(2):225-37. doi: 10.1016/0092-8674(94)90293-3.
Members of the TGF beta superfamily of secreted signaling molecules regulate growth and cellular patterning during development and interact with specific type I and type II membrane receptors possessing a cytoplasmic serine/threonine kinase domain. We describe two members of the type I receptor family in Drosophila and demonstrate that they are encoded by the genes saxophone (sax) and thick veins (tkv). Further, we show that mutations that abolish sax or tkv activity cause phenotypes similar to partial or complete loss of activity, respectively, of the TGF beta homolog decapentaplegic (dpp). We propose that specification of distinct cell fates in response to different concentrations of dpp may be achieved combinatorially by the sax and tkv receptors.
分泌型信号分子TGF-β超家族的成员在发育过程中调节生长和细胞模式，并与具有细胞质丝氨酸/苏氨酸激酶结构域的特定I型和II型膜受体相互作用。我们描述了果蝇中I型受体家族的两个成员，并证明它们由萨克斯风（sax）和粗脉（tkv）基因编码。此外，我们表明，消除sax或tkv活性的突变分别导致与TGF-β同源物截瘫（dpp）的部分或完全活性丧失相似的表型。我们提出，响应不同浓度的dpp，通过sax和tkv受体组合可能实现不同细胞命运的特化。
