Ruberte E, Marty T, Nellen D, Affolter M, Basler K
Biozentrum Universität Basel Switzerland.
Cell. 1995 Mar 24;80(6):889-97. doi: 10.1016/0092-8674(95)90292-9.
TGF beta elicits diverse cellular responses by signaling through receptor complexes formed by two distantly related transmembrane serine/threonine kinases called type II and type I receptors. Previous studies have indicated that the product of the Drosophila thick veins (tkv) gene is a type I receptor for decapentaplegic (dpp). Here, we show that the Drosophila gene punt encodes a homolog of a vertebrate type II receptor, and we demonstrate that punt, like tkv, is essential in vivo for dpp-dependent patterning processes. Because no dpp-related signalling is apparent in the absence of either the punt or tkv receptor, we infer that both receptors act in concert to transduce the dpp signal and that their functions cannot be replaced by the other extant type II and I receptors.
转化生长因子β（TGFβ）通过与由两种远亲跨膜丝氨酸/苏氨酸激酶（称为II型和I型受体）形成的受体复合物进行信号传导，引发多种细胞反应。先前的研究表明，果蝇粗脉（tkv）基因的产物是一种针对果蝇五体不全（dpp）的I型受体。在这里，我们表明果蝇基因punt编码一种脊椎动物II型受体的同源物，并且我们证明，与tkv一样，punt在体内对于依赖dpp的模式形成过程至关重要。由于在没有punt或tkv受体的情况下没有明显的dpp相关信号传导，我们推断这两种受体协同作用以转导dpp信号，并且它们的功能不能被其他现存的II型和I型受体所取代。
