Gwilt P R, Lear C L, Tempero M A, Birt D D, Grandjean A C, Ruddon R W, Nagel D L
College of Pharmacy, Eppley Institute, University of Nebraska Medical Center, Omaha 68131.
Cancer Epidemiol Biomarkers Prev. 1994 Mar;3(2):155-60.
Several studies suggest that the constituents of garlic may inhibit experimentally induced carcinogenesis. To evaluate the chemopreventive properties of garlic in humans, the effects of chronic administration of an aged garlic extract on the disposition of acetaminophen and metabolites were studied. This commonly used drug was chosen because it forms a reactive electrophilic metabolite after oxidative metabolism. Sixteen subjects ingested daily doses of garlic extract (approximately equivalent to six to seven cloves of garlic) for 3 months. Before the course of garlic, at the end of each month and 1 month after termination of garlic administration, a 1-g oral dose of acetaminophen was given to each subject. Plasma and urine were measured for acetaminophen and the glucuronide, sulfate, cysteinyl, mercapturate, and methylthio metabolites. It was found that garlic treatment had no discernible effect on oxidative metabolism but was associated with a slight increase in sulfate conjugation of drug. These findings suggest that garlic extract has limited potential as a chemopreventive agent.
多项研究表明，大蒜的成分可能抑制实验诱导的致癌作用。为评估大蒜对人体的化学预防特性，研究了长期服用陈年大蒜提取物对乙酰氨基酚及其代谢产物处置的影响。选择这种常用药物是因为它在氧化代谢后会形成一种反应性亲电代谢产物。16名受试者连续3个月每日服用大蒜提取物（约相当于6至7瓣大蒜）。在服用大蒜疗程前、每个月末以及停止服用大蒜1个月后，给每位受试者口服1克乙酰氨基酚。检测血浆和尿液中的乙酰氨基酚及其葡萄糖醛酸苷、硫酸盐、半胱氨酰、硫醚氨酸和甲硫基代谢产物。结果发现，大蒜治疗对氧化代谢没有明显影响，但与药物硫酸盐结合略有增加有关。这些发现表明，大蒜提取物作为化学预防剂的潜力有限。
