星状病毒的细胞培养适应性涉及一个缺失。
Cell culture adaptation of astrovirus involves a deletion.
作者信息
Willcocks M M, Ashton N, Kurtz J B, Cubitt W D, Carter M J
机构信息
School of Biological Sciences, University of Surrey, Guildford, United Kingdom.
出版信息
J Virol. 1994 Sep;68(9):6057-8. doi: 10.1128/JVI.68.9.6057-6058.1994.
Abstract
Astroviruses have been adapted to culture by serial blind passage in primary human embryo cells. All viruses thus adapted possess a 45-nucleotide deletion relative to fecal viruses or isolates made in CaCo-2 cells; this deletion may be responsible for the change in host cell range.
摘要
星状病毒已通过在原代人胚细胞中连续盲传适应培养。相对于粪便病毒或在CaCo-2细胞中产生的分离株，所有如此适应的病毒都有一个45个核苷酸的缺失；这种缺失可能是宿主细胞范围变化的原因。
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