Monroe S S, Jiang B, Stine S E, Koopmans M, Glass R I
Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
J Virol. 1993 Jun;67(6):3611-4. doi: 10.1128/JVI.67.6.3611-3614.1993.
We report the sequence of the subgenomic RNA of human astrovirus serotype 2. This 2,484-nucleotide RNA contains a single open reading frame, which encodes a protein with a predicted molecular mass of 88 kDa. We propose that this protein is the 90-kDa capsid precursor observed in infected cells. The deduced protein sequence does not contain conserved amino acid patterns reported for the capsid proteins of picornaviruses or caliciviruses, consistent with the classification of astroviruses as a new family of RNA viruses, designated Astroviridae.
我们报告了人星状病毒2型亚基因组RNA的序列。这条2484个核苷酸的RNA含有一个单一的开放阅读框，编码一种预测分子量为88 kDa的蛋白质。我们认为该蛋白质是在受感染细胞中观察到的90 kDa衣壳前体。推导的蛋白质序列不包含已报道的微小核糖核酸病毒或杯状病毒衣壳蛋白的保守氨基酸模式，这与星状病毒被归类为一个新的RNA病毒科——星状病毒科相一致。
