1型人类星状病毒衣壳蛋白基因的鉴定与序列测定
Identification and sequence determination of the capsid protein gene of human astrovirus serotype 1.
作者信息
Willcocks M M, Carter M J
机构信息
Division of Virology, School of Pathological Sciences, Medical School, University of Newcastle-upon-Tyne, UK.
出版信息
FEMS Microbiol Lett. 1993 Nov 15;114(1):1-7. doi: 10.1016/0378-1097(93)90133-m.
Abstract
We present the sequence of an open reading frame (ORF) at the 3' end of human astrovirus serotype 1. Primer extension experiments showed that the RNA expressing this gene is shorter than the complete ORF, and could form a protein of M(r) 85,540. The protein was expressed by recombinant baculovirus and was recognized by anti-virion serum, indicating a structural role. Sequence comparison indicates that astrovirus serotypes 1 and 2 differ markedly in the C-terminal half of the protein but are well conserved towards the N-terminus.
摘要
我们展示了人1型星状病毒3'端一个开放阅读框（ORF）的序列。引物延伸实验表明，表达该基因的RNA短于完整的ORF，且可形成分子量为85,540的蛋白质。该蛋白质由重组杆状病毒表达，并可被抗病毒粒子血清识别，表明其具有结构作用。序列比较表明，1型和2型星状病毒在该蛋白质的C端一半区域差异显著，但在N端则高度保守。
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