Williams S V, Pattison C P, Berquist K R
JAMA. 1975 Jun 23;232(12):1231-3.
We performed a prospective study to assess the risk of patients acquiring infection following routine professional contact with two dentists incubating type B viral hepatitis. Serum samples from patients exposed during the six weeks before onset of hepatitis in the dentists were tested for hepatitis B surface antigen and for antibody to the antigen shortly after illness developed and again six months later. Household members of exposed patients served as a control group. None of the exposed patients or controls became ill with hepititis, and none developed antigen. Three of the 237 exposed patients developed antibody, as did four of the 245 controls. The difference between exposed patients and controls was not significant. These results do not support the hypothesis that these two dentists transmitted infection to their patients.
我们进行了一项前瞻性研究,以评估患者在与两名感染乙型病毒性肝炎的牙医进行常规专业接触后感染的风险。在牙医肝炎发病前六周内接触过的患者的血清样本,在疾病发生后不久以及六个月后再次检测乙型肝炎表面抗原和该抗原的抗体。接触过的患者的家庭成员作为对照组。所有接触过的患者和对照组均未患肝炎,也未产生抗原。237名接触过的患者中有3人产生了抗体,245名对照组中有4人产生了抗体。接触过的患者与对照组之间的差异不显著。这些结果不支持这两名牙医将感染传播给患者的假设。