饮用水致突变性与胃肠道和泌尿系统癌症：芬兰的一项生态学研究
Drinking water mutagenicity and gastrointestinal and urinary tract cancers: an ecological study in Finland.
作者信息
Koivusalo M, Jaakkola J J, Vartiainen T, Hakulinen T, Karjalainen S, Pukkala E, Tuomisto J
机构信息
Finnish Cancer Registry, Helsinki.
出版信息
Am J Public Health. 1994 Aug;84(8):1223-8. doi: 10.2105/ajph.84.8.1223.
OBJECTIVES
The purpose of this study was to investigate the relationship between exposure to mutagenic drinking water and cancers of the gastrointestinal and urinary tract.
METHODS
Past exposure to drinking water mutagenicity was assessed in 56 Finnish municipalities for the years 1955 and 1970. The cases of bladder, kidney, stomach, colon, and rectum cancers were derived from two periods (1967 to 1976 and 1977 to 1986). Age, sex, social class, urban living, and time period were taken into account in the Poisson regression analysis.
RESULTS
Statistically significant exposure-response association was observed between exposure and incidence of bladder, kidney, and stomach cancers. In an ordinary municipality using chlorinated surface water, this exposure would indicate a relative risk of 1.2 for bladder cancer and of 1.2 to 1.4 for kidney cancer compared with municipalities where nonmutagenic drinking water was consumed.
CONCLUSIONS
The acidic mutagenic compounds present in drinking water may play a role in the etiology of kidney and bladder cancers, but, because the results are based on aggregate data, they should be interpreted with caution.
目的
本研究旨在调查接触致突变性饮用水与胃肠道和泌尿系统癌症之间的关系。
方法
评估了芬兰56个城市在1955年和1970年饮用水的致突变性。膀胱癌、肾癌、胃癌、结肠癌和直肠癌病例来自两个时期（1967年至1976年和1977年至1986年）。在泊松回归分析中考虑了年龄、性别、社会阶层、城市生活和时间段。
结果
在接触与膀胱癌、肾癌和胃癌发病率之间观察到具有统计学意义的暴露-反应关联。在一个使用氯化地表水的普通城市，与饮用非致突变性饮用水的城市相比，这种接触表明膀胱癌的相对风险为1.2，肾癌的相对风险为1.2至1.4。
结论
饮用水中存在的酸性致突变化合物可能在肾癌和膀胱癌的病因中起作用，但由于结果基于汇总数据，应谨慎解释。
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