爱荷华州绝经后女性饮用水源及氯化副产物与癌症发病率的关联：一项前瞻性队列研究
The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: a prospective cohort study.
作者信息
Doyle T J, Zheng W, Cerhan J R, Hong C P, Sellers T A, Kushi L H, Folsom A R
机构信息
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.
出版信息
Am J Public Health. 1997 Jul;87(7):1168-76. doi: 10.2105/ajph.87.7.1168.
Abstract
OBJECTIVES
This study assessed the association of drinking water source and chlorination by-product exposure with cancer incidence.
METHODS
A cohort of 28,237 Iowa women reported their drinking water source. Exposure to chlorination by-products was determined from statewide water quality data.
RESULTS
In comparison with women who used municipal ground-water sources, women with municipal surface water sources were at an increased risk of colon cancer and all cancers combined. A clear dose-response relation was observed between four categories of increasing chloroform levels in finished drinking water and the risk of colon cancer and all cancers combined. The relative risks were 1.00, 1.06, 1.39, and 1.68 for colon cancer and 1.00, 1.04, 1.24, and 1.25 for total cancers. No consistent association with either water source or chloroform concentration was observed for other cancer sites.
CONCLUSIONS
These results suggest that exposure to chlorination by-products in drinking water is associated with increased risk of colon cancer.
摘要
目的
本研究评估饮用水水源及氯消毒副产物暴露与癌症发病率之间的关联。
方法
一个由28237名爱荷华州女性组成的队列报告了她们的饮用水水源。通过全州水质数据确定氯消毒副产物的暴露情况。
结果
与使用市政地下水水源的女性相比，使用市政地表水水源的女性患结肠癌及所有癌症合并症的风险增加。在成品饮用水中氯仿水平升高的四个类别与结肠癌及所有癌症合并症的风险之间观察到明确的剂量反应关系。结肠癌的相对风险分别为1.00、1.06、1.39和1.68，所有癌症的相对风险分别为1.00、1.04、1.24和1.25。在其他癌症部位未观察到与水源或氯仿浓度的一致关联。
结论
这些结果表明，饮用水中氯消毒副产物的暴露与结肠癌风险增加有关。
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