金黄色葡萄球菌J2870中编码高水平莫匹罗星抗性基因的分子特征
Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870.
作者信息
Hodgson J E, Curnock S P, Dyke K G, Morris R, Sylvester D R, Gross M S
机构信息
Department of Biotechnology, SmithKline Beecham Pharmaceuticals, Brockham Park, Betchworth Surrey, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1994 May;38(5):1205-8. doi: 10.1128/AAC.38.5.1205.
Abstract
The nucleotide sequence of the ileS gene conferring high-level resistance to mupirocin in Staphylococcus aureus J2870 has been determined. The gene sequence is substantially different from that of the native ileS gene of S. aureus, indicating that high-level resistance to mupirocin results from the acquisition of a novel ileS gene.
摘要
已确定金黄色葡萄球菌J2870中赋予对莫匹罗星高水平抗性的ileS基因的核苷酸序列。该基因序列与金黄色葡萄球菌天然ileS基因的序列有很大不同，表明对莫匹罗星的高水平抗性是由于获得了一个新的ileS基因。
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