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金黄色葡萄球菌J2870中编码高水平莫匹罗星抗性基因的分子特征

Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870.

作者信息

Hodgson J E, Curnock S P, Dyke K G, Morris R, Sylvester D R, Gross M S

机构信息

Department of Biotechnology, SmithKline Beecham Pharmaceuticals, Brockham Park, Betchworth Surrey, United Kingdom.

出版信息

Antimicrob Agents Chemother. 1994 May;38(5):1205-8. doi: 10.1128/AAC.38.5.1205.

DOI:10.1128/AAC.38.5.1205
PMID:8067768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188182/
Abstract

The nucleotide sequence of the ileS gene conferring high-level resistance to mupirocin in Staphylococcus aureus J2870 has been determined. The gene sequence is substantially different from that of the native ileS gene of S. aureus, indicating that high-level resistance to mupirocin results from the acquisition of a novel ileS gene.

摘要

已确定金黄色葡萄球菌J2870中赋予对莫匹罗星高水平抗性的ileS基因的核苷酸序列。该基因序列与金黄色葡萄球菌天然ileS基因的序列有很大不同，表明对莫匹罗星的高水平抗性是由于获得了一个新的ileS基因。

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Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870.金黄色葡萄球菌J2870中编码高水平莫匹罗星抗性基因的分子特征
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本文引用的文献

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High-level mupirocin resistance in Staphylococcus aureus: evidence for two distinct isoleucyl-tRNA synthetases.金黄色葡萄球菌中高水平莫匹罗星耐药性：两种不同异亮氨酰 - tRNA合成酶的证据。
Antimicrob Agents Chemother. 1993 Jan;37(1):32-8. doi: 10.1128/AAC.37.1.32.
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Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase.编码异亮氨酰 - tRNA合成酶的葡萄球菌基因在大肠杆菌中的分析及毒性过表达
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Unique features in the ribosome binding site sequence of the gram-positive Staphylococcus aureus beta-lactamase gene.革兰氏阳性金黄色葡萄球菌β-内酰胺酶基因核糖体结合位点序列的独特特征。
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Specific sequence homology and three-dimensional structure of an aminoacyl transfer RNA synthetase.氨酰基转移RNA合成酶的特定序列同源性和三维结构
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Interaction of pseudomonic acid A with Escherichia coli B isoleucyl-tRNA synthetase.假单胞菌酸A与大肠杆菌B异亮氨酰-tRNA合成酶的相互作用。
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Bacillus subtilis requires a "stringent" Shine-Dalgarno region for gene expression.枯草芽孢杆菌的基因表达需要一个“严格的”夏因-达尔加诺序列区域。
DNA. 1984;3(1):17-21. doi: 10.1089/dna.1.1984.3.17.
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Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens.假单胞菌酸：一种由荧光假单胞菌产生的抗生素。
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In-vitro activity of mupirocin ('pseudomonic acid') against clinical isolates of Staphylococcus aureus.莫匹罗星（“假单胞菌酸”）对金黄色葡萄球菌临床分离株的体外活性。
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10
Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use.莫匹罗星（假单胞菌酸）——一种新型局部用抗生素的抗菌活性
Antimicrob Agents Chemother. 1985 Apr;27(4):495-8. doi: 10.1128/AAC.27.4.495.