Linn T, Losick R, Sonenshein A L
J Bacteriol. 1975 Jun;122(3):1387-90. doi: 10.1128/jb.122.3.1387-1390.1975.
The rifampin-resistance mutation of LS3,an asporogenous mutant of Bacillus subtilis 3610, leads to altered mobility of the beta subunit of ribonucleic acid polymerase in sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis. This finding argues that the rifampin-resistance mutation is located in the structural gene coding for the beta polypeptide.
枯草芽孢杆菌3610的无芽孢突变体LS3的利福平抗性突变,导致在十二烷基硫酸钠-聚丙烯酰胺平板凝胶电泳中核糖核酸聚合酶β亚基的迁移率发生改变。这一发现表明,利福平抗性突变位于编码β多肽的结构基因中。