Tanaka N, Amagasa T, Iwaki H, Shioda S, Takeda M, Ohashi K, Reck S F
First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.
Oral Surg Oral Med Oral Pathol. 1994 Jul;78(1):81-90. doi: 10.1016/0030-4220(94)90121-x.
Clinical examination was performed on 20 cases of malignant melanoma in the oral region encountered at the First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, during the 22-year period from 1970 to 1991. In addition, we reviewed 140 cases reported in the Japanese literature since the last major review in 1974. The results of our study revealed that the clinical course of malignant melanoma in the oral region is worse than oral squamous cell carcinoma and that treatment by radiotherapy is effective in prolonging the life of these patients. Clinically, the tumors were classified into five types: (1) pigmented nodular type; (2) nonpigmented nodular type; (3) pigmented macular type; (4) pigmented mixed type; and (5) nonpigmented mixed type. We suggest that oral malignant melanoma might be different from cutaneous malignant melanoma and that new criteria for diagnosis and therapy for oral disease should be considered.
对东京医科齿科大学齿学部口腔颌面外科第一科室在1970年至1991年的22年间收治的20例口腔区域恶性黑色素瘤患者进行了临床检查。此外，我们还回顾了自1974年上次重大综述以来日本文献报道的140例病例。我们的研究结果显示，口腔区域恶性黑色素瘤的临床病程比口腔鳞状细胞癌更差，放疗治疗可有效延长这些患者的生命。临床上，肿瘤分为五种类型：（1）色素性结节型；（2）无色素结节型；（3）色素性斑疹型；（4）色素性混合型；（5）无色素混合型。我们认为口腔恶性黑色素瘤可能与皮肤恶性黑色素瘤不同，应考虑制定口腔疾病诊断和治疗的新标准。
