Shibuya H, Takeda M, Matsumoto S, Hoshina M, Suzuki S, Takagi M
Department of Radiology, Tokyo Medical and Dental University, Japan.
Int J Radiat Oncol Biol Phys. 1993 Jan;25(1):35-9. doi: 10.1016/0360-3016(93)90142-i.
An analysis has been made of the effect of radiation therapy in 28 patients with a malignant melanoma (Stage I: 18 cases; Stage II: 10 cases) in the mucosa of the upper jaw. Treatment had been provided by one of the following methods: intraoral mold (10 cases), interstitial brachytherapy (two cases), intraoral electron therapy (nine cases), or external irradiation (seven cases). The results have shown that the survival rate for all 28 patients was 25%, and that the survival rate for stage I patients treated by intraoral electron or brachytherapy was 47%. The primary tumor control rate in percentages was 79% (22/28) in all 28 radiotherapy patients; 92% (11/12) for tumors treated by a mold or an interstitial implant; 67% (6/9) for tumors treated by an intraoral cone; and 71% (5/7) for tumors treated by external irradiation with or without surgery. A neck metastasis that was found in 19 patients was treated by surgery, radiotherapy, and/or immunochemotherapy, and the result was successful in nine patients. The major factor in the failure of treatment was a distant, metastatic dissemination. This analysis revealed that radiotherapy has achieved similar or better results than surgery and may be advocated for the management of a localized malignant melanoma in the mucosa of the upper jaw.
对28例上颌黏膜恶性黑色素瘤患者（I期：18例；II期：10例）的放射治疗效果进行了分析。治疗采用以下方法之一：口腔内模具放疗（10例）、组织间近距离放疗（2例）、口腔内电子线放疗（9例）或外照射（7例）。结果显示，28例患者的总生存率为25%，I期患者经口腔内电子线放疗或近距离放疗后的生存率为47%。28例接受放疗患者的原发肿瘤控制率为79%（22/28）；采用模具或组织间植入治疗的肿瘤控制率为92%（11/12）；口腔内锥形放疗的肿瘤控制率为67%（6/9）；外照射联合或不联合手术治疗的肿瘤控制率为71%（5/7）。19例出现颈部转移的患者接受了手术、放疗和/或免疫化疗，9例治疗成功。治疗失败的主要因素是远处转移扩散。该分析表明，放射治疗取得了与手术相似或更好的效果，对于上颌黏膜局限性恶性黑色素瘤的治疗可能是可取的。
