Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110000, China.
Mol Med. 2023 Jul 5;29(1):90. doi: 10.1186/s10020-023-00689-4.
Abnormal microbial colonization in the gut at an early stage of life affects growth, development, and health, resulting in short- and long-term adverse effects. Microbial colonization patterns of preterm infants differ from those of full-term infants in that preterm babies and their mothers have more complicated prenatal and postnatal medical conditions. Maternal complications, antibiotic exposure, delivery mode, feeding type, and the use of probiotics may significantly shape the gut microbiota of preterm infants at an early stage of life; however, these influences subside with age. Although some factors and processes are difficult to intervene in or avoid, understanding the potential factors and determinants will help in developing timely strategies for a healthy gut microbiota in preterm infants. This review discusses potential determinants of gut microbial colonization in preterm infants and their underlying mechanisms.
早期生命中肠道内异常微生物定植会影响生长、发育和健康，导致短期和长期的不良影响。早产儿的微生物定植模式与足月儿不同，早产儿及其母亲有更复杂的产前和产后医疗条件。母体并发症、抗生素暴露、分娩方式、喂养类型和益生菌的使用可能会在生命早期显著影响早产儿的肠道微生物群，但这些影响会随着年龄的增长而减弱。虽然有些因素和过程难以干预或避免，但了解潜在因素和决定因素将有助于为早产儿建立健康的肠道微生物群制定及时的策略。本综述讨论了早产儿肠道微生物定植的潜在决定因素及其潜在机制。
