戊型肝炎病毒传播给一名志愿者。

Hepatitis E virus transmission to a volunteer.

作者信息

Chauhan A, Jameel S, Dilawari J B, Chawla Y K, Kaur U, Ganguly N K

机构信息

Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Lancet. 1993 Jan 16;341(8838):149-50. doi: 10.1016/0140-6736(93)90008-5.

DOI:10.1016/0140-6736(93)90008-5

PMID:8093748

Abstract

Hepatitis E virus (HEV) causes an enteric non-A, non-B hepatitis. The disease occurs in epidemic settings and sporadically, and viral transmission is thought to be faecal-oral. We present here a single volunteer study of HEV transmission followed by disease. Clinical and biochemical features of the infection correlated with HEV detection in the stools and sera by reverse transcription/polymerase chain amplification. IgG antibody has persisted for 2 years. The presence of HEV in serum before clinical signs appeared suggests that in endemic areas sporadic transmission of HEV may also occur parenterally.

摘要

戊型肝炎病毒（HEV）引起一种肠道非甲非乙型肝炎。该疾病以流行形式出现，也有散发病例，病毒传播被认为是粪口途径。我们在此展示了一项关于戊型肝炎病毒传播及后续疾病的单志愿者研究。感染的临床和生化特征与通过逆转录/聚合酶链扩增在粪便和血清中检测到的戊型肝炎病毒相关。IgG抗体持续了2年。在临床症状出现之前血清中存在戊型肝炎病毒表明，在流行地区，戊型肝炎病毒的散发性传播也可能通过非肠道途径发生。